Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii

被引：116

作者：

Kopanska, K

Najda, A

Zebrowska, J

Chomicz, L

Piekarczyk, J

Myjak, P

Bretner, M

机构：

[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

[2] Med Univ Warsaw, Dept Med Biol, PL-02018 Warsaw, Poland

[3] Med Univ Warsaw, Dept Maxillofacial Surg 2, PL-02005 Warsaw, Poland

[4] Med Univ Gdansk, Dept Trop Parasitol, PL-081516 Gdynia, Poland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 10期

关键词：

analogues of 1H-benzimidazole; analogues of 1H-benzotriazole; Acanthamoeba castellanii; antiprotozoal activity;

D O I：

10.1016/j.bmc.2004.03.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2617 / 2624

页数：8

共 37 条

[1] Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses [J].