A new sensitive spectrophotometric method for the analysis of some antihistamines

被引：10

作者：

Daabees, HG ^{[1
]}

机构：

[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt

来源：

SPECTROSCOPY LETTERS | 1999年 / 32卷 / 06期

关键词：

astemizole; cinnarizine; mequitazine; terfenadine; Picrolonic acid; spectrophotometry;

D O I：

10.1080/00387019909350037

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A simple and sensitive spectrophotometric method is developed for the assay of some antihistamines. The method is based on the interaction of these basic compounds with picrolonic acid in chloroform to give a yellow color exhibiting maximum absorption at 359 nm. The drugs determined are astemizole, cinnarizine, mequitazine and terfenadine. Beer's Law is valid for the investigated antihistamines. The drugs are determined either in pure form or in their pharmaceutical formulations. The sensitivity of the proposed procedure is discussed and the results are compared with reported ones.

引用

页码：913 / 930

页数：18

共 35 条

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