Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice

被引：31

作者：

Fu, Xian-Pei ^{[1
,2
]}

Xu, Lin ^{[1
]}

Fu, Bin-Bin ^{[1
]}

Wei, Kang-Na ^{[1
,3
]}

Liu, Yu ^{[1
,4
]}

Liao, Bao-Qiong ^{[1
]}

He, Shu-Wen ^{[1
]}

Wang, Ya-Long ^{[1
,5
]}

Chen, Ming-Huang ^{[1
]}

Lin, Yan-Hong ^{[1
,6
]}

Li, Fei-Ping ^{[1
,7
]}

Hong, Zi-Wei ^{[1
]}

Huang, Xiao-Hua ^{[8
]}

Xu, Chang-Long ^{[9
]}

Wang, Hai-Long ^{[1
,8
]}

机构：

[1] Xiamen Univ, Sch Med, Organ Transplantat Inst, Xiamen, Peoples R China

[2] Shanxi Med Univ, Clin Pharm Off, Taiyuan Cent Hosp, Taiyuan, Peoples R China

[3] Xiamen Univ, Dept Gynaecol & Obstet, Affiliated Xiangan Hosp, Xiamen, Peoples R China

[4] Guangxi Univ, Med Coll, Nanning, Peoples R China

[5] Maternal & Child Hlth Care Hosp, Reprod Med Ctr, Xiangtan, Peoples R China

[6] Putian Univ, Affiliated Hosp, Dept Gynaecol, Putian, Peoples R China

[7] Chengdu Res Base Giant Panda Breeding, Sichuan Key Lab Conservat Biol Endangered Wildlif, Chengdu, Peoples R China

[8] Xiamen Univ, Sch Med, Dept Basic Med, Xiang An S Rd, Xiamen 361102, Fujian, Peoples R China

[9] Nanning Second Peoples Hosp, Reprod Med Ctr, Dancun Rd 13, Nanning 530031, Peoples R China

来源：

BIOLOGY OF REPRODUCTION | 2020年 / 103卷 / 05期

基金：

中国国家自然科学基金;

关键词：

pachymic acid; PCOS; oocyte; embryo; mice; metformin; KINASE; CELL;

D O I：

10.1093/biolre/ioaa141

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a PCOS mice model by hypodermic injection of dehydroepiandrosterone, and metformin was used as a positive control drug to study the effect of pachymic acid (PA) on endocrine and oocyte quality in PCOS mice. Compared with the model group, the mice treated with PA showed the following changes (slower weight gain, improved abnormal metabolism; increased development potential of GV oocytes, reduced number of abnormal MII oocytes, and damaged embryos; lower expression of ovarianrelated genes in ovarian tissue and pro-inflammatory cytokines in adipose tissue). All these aspects show similar effects on metformin. Most notably, PA is superior to metformin in improving inflammation of adipose tissue and mitochondria! abnormalities. It is suggested that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. These findings suggest that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. [GRAPHICS] .

引用

页码：1085 / 1098

页数：14

共 27 条

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Oxidative stress and its implications in female infertility - a clinician's perspective [J].