The current state of immunotherapy for gliomas: an eye toward the future

被引：84

作者：

Fecci, Peter E. ^{[1
,2
]}

Sampson, John H. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Duke Brain Tumor Immunotherapy Program, Dept Neurosurg, Durham, NC USA

[2] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr Duke, Dept Neurosurg, Durham, NC USA

来源：

JOURNAL OF NEUROSURGERY | 2019年 / 131卷 / 03期

关键词：

glioblastoma; immunotherapy; T-lymphocytes; immunosuppression; cancer vaccines; brain neoplasms; oncology; GROWTH-FACTOR RECEPTOR; PRIMARY INTRACRANIAL TUMORS; T-CELL EXHAUSTION; GLIOBLASTOMA-MULTIFORME; HUMAN CYTOMEGALOVIRUS; PEPTIDE VACCINATION; MISMATCH REPAIR; EXPRESSION; REGRESSION; BLOCKADE;

D O I：

10.3171/2019.5.JNS181762

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The last decade has seen a crescendo of FDA approvals for immunotherapies against solid tumors, yet glioblastoma remains a prominent holdout. Despite more than 4 decades of work with a wide range of immunotherapeutic modalities targeting glioblastoma, efficacy has been challenging to obtain. Earlier forms of immune-based platforms have now given way to more current approaches, including chimeric antigen receptor T-cells, personalized neoantigen vaccines, oncolytic viruses, and checkpoint blockade. The recent experiences with each, as well as the latest developments and anticipated challenges, are reviewed.

引用

页码：657 / 666

页数：10

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