High prevalence of herpes simplex virus type 2 in acute retinal necrosis syndrome associated with herpes simplex virus in Japan

被引：40

作者：

Itoh, N ^{[1
]}

Matsumura, N ^{[1
]}

Ogi, A ^{[1
]}

Nishide, T ^{[1
]}

Imai, Y ^{[1
]}

Kanai, H ^{[1
]}

Ohno, S ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Ophthalmol, Kanazawa Ku, Yokohama, Kanagawa 236, Japan

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 2000年 / 129卷 / 03期

关键词：

D O I：

10.1016/S0002-9394(99)00391-8

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To determine the type of herpes simplex virus in acute retinal necrosis syndrome associated with herpes simplex virus. METHODS: Herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus were examined by polymerase chain reaction in intraocular specimens from 16 patients with acute retinal necrosis syndrome. Anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 type-specific antibodies in serum from the patients were detected by enzyme immunoassay. RESULTS: Of 16 patients with acute retinal necrosis syndrome, seven were polymerase chain reaction positive for herpes simplex virus type 2 and nine were positive for varicella-zoster virus, Anti-herpes simplex virus type 2 antibody was positive and antiherpes simplex virus type 1 antibody was negative in the sera of the seven patients with herpes simplex virus type 2 DNA-positive acute retinal necrosis syndrome. In contrast, anti-herpes simplex virus type 2 antibody was absent in all nine varicella-zoster virus DNA-positive acute retinal necrosis syndrome patients. CONCLUSION: Herpes simplex virus type 2 has been demonstrated to be the major causative agent in acute retinal necrosis syndrome associated with herpes simplex virus by molecular biological and serological methods. Negative preexisting anti-herpes simplex virus type 1 antibody may play an important role in acute retinal necrosis syndrome associated with herpes simplex virus type 2. (C) 2000 by Elsevier Science Inc. All rights reserved.

引用

页码：404 / 405

页数：2

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