Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

被引：100

作者：

Monfrecola, Giuseppe ^{[1
]}

Lembo, Serena ^{[1
]}

Caiazzo, Giuseppina ^{[1
]}

De Vita, Valerio ^{[1
]}

Di Caprio, Roberta ^{[1
]}

Balato, Anna ^{[1
]}

Fabbrocini, Gabriella ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Dermatol, Via S Pansini 5, I-80131 Naples, Italy

来源：

EXPERIMENTAL DERMATOLOGY | 2016年 / 25卷 / 02期

关键词：

acne; HOMA-IR; mechanistic target of rapamycin; mTOR; FOXO1;

D O I：

10.1111/exd.12885

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

[No abstract available]

引用

收藏

页码：153 / 155

页数：3

相关论文

共 9 条

[1]

MAMMALIAN TARGET OF RAPAMYCIN IN INFLAMMATORY SKIN CONDITIONS [J].

Balato, A. ;

Di Caprio, R. ;

Lembo, S. ;

Mattii, M. ;

Megna, M. ;

Schiattarella, M. ;

Tarantino, G. ;

Balato, N. ;

Ayala, F. ;

Monfrecola, G. .

EUROPEAN JOURNAL OF INFLAMMATION, 2014, 12 (02) :341-350

[2]

A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].

BROWN, EJ ;

ALBERS, MW ;

SHIN, TB ;

ICHIKAWA, K ;

KEITH, CT ;

LANE, WS ;

SCHREIBER, SL .

NATURE, 1994, 369 (6483) :756-758

[3]

Insulin resistance and acne: a new risk factor for men? [J].

Del Prete, Michela ;

Mauriello, Maria Chiara ;

Faggiano, Antongiulio ;

Di Somma, Carolina ;

Monfrecola, Giuseppe ;

Fabbrocini, Gabriella ;

Colao, Annamaria .

ENDOCRINE, 2012, 42 (03) :555-560

[4]

The hypothetical role of FoxO1 in acne is interesting, but more study is needed before any conclusions can be drawn [J].

Leyden, J. J. ;

Gollnick, H. ;

Thiboutot, D. ;

Dreno, B. ;

Bettoli, V. ;

Kang, S. ;

Shalita, A. ;

Torres, V. .

BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (06) :1365-1366

[5]

Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance [J].

Melnik, Bodo C. ;

John, Swen Malte ;

Plewig, Gerd .

ACTA DERMATO-VENEREOLOGICA, 2013, 93 (06) :644-649

[6]

Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? [J].

Melnik, Bodo C. ;

Schmitz, Gerd .

EXPERIMENTAL DERMATOLOGY, 2013, 22 (07) :502-504

[7]

Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne [J].

Melnik, Bodo C. ;

Zouboulis, Christos C. .

EXPERIMENTAL DERMATOLOGY, 2013, 22 (05) :311-315

[8]

Dietary intervention in acne Attenuation of increased mTORC1 signaling promoted by Western diet [J].

Melnik, Bodo C. .

DERMATO-ENDOCRINOLOGY, 2012, 4 (01) :20-32

[9]

Mammalian target of rapamycin, insulin resistance and hidradenitis suppurativa: a possible metabolic loop [J].

Monfrecola, G. ;

Balato, A. ;

Caiazzo, G. ;

De Vita, V. ;

Di Caprio, R. ;

Donnarumma, M. ;

Lembo, S. ;

Fabbrocini, G. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2016, 30 (09) :1631-1633