Induction of HIV-1 specific mucosal immune responses by DNA vaccination

被引：38

作者：

Asakura, Y

Hinkula, J

Leandersson, AC

Fukushima, J

Okuda, K

Wahren, B

机构：

[1] KAROLINSKA INST, CTR MICROBIOL & TUMOR BIOL, S-10521 STOCKHOLM, SWEDEN

[2] SWEDISH INST INFECT DIS CONTROL, STOCKHOLM, SWEDEN

[3] YOKOHAMA CITY UNIV, SCH MED, YOKOHAMA, KANAGAWA 232, JAPAN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1997年 / 46卷 / 04期

关键词：

D O I：

10.1046/j.1365-3083.1997.d01-146.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.

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页码：326 / 330

页数：5

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