New roles for old holes: Ion channel function in aquaporin-1

被引：92

作者：

Yool, AJ ^{[1
]}

Weinstein, AM

机构：

[1] Univ Arizona, Coll Med, Dept Pharmacol, Dept Physiol, Tucson, AZ 85724 USA

[2] Cornell Univ, Weill Med Coll, Dept Physiol, New York, NY 10021 USA

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/nips.01372.2001

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mammalian aquaporins are part of the diverse major intrinsic protein family of water and solute channels. Intriguing links exist in structural and functional properties between aquaporins and ion channels. A novel role for aquaporin-1 as a gated ion channel reshapes our current views of this ancient family of transmembrane channel proteins.

引用

页码：68 / 72

页数：5

共 19 条

[1] Cloned human aquaporin-1 is a cyclic GMP-gated ion channel [J].

Anthony, TL ;

Brooks, HL ;

Boassa, D ;

Leonov, S ;

Yanochko, GM ;

Regan, JW ;

Yool, AJ .

MOLECULAR PHARMACOLOGY, 2000, 57 (03) :576-588

[2]

Brooks HL, 2000, MOL PHARMACOL, V57, P1021

[3] EphB2 guides axons at the midline and is necessary for normal vestibular function [J].

Cowan, CA ;

Yokoyama, N ;

Bianchi, LM ;

Henkemeyer, M ;

Fritzsch, B .

NEURON, 2000, 26 (02) :417-430

[4] NITRIC-OXIDE AND ANGIOTENSIN-II - GLOMERULAR AND TUBULAR INTERACTION IN THE RAT [J].

DENICOLA, L ;

BLANTZ, RC ;

GABBAI, FB .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (04) :1248-1256

[5] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].

Doyle, DA ;

Cabral, JM ;

Pfuetzner, RA ;

Kuo, AL ;

Gulbis, JM ;

Cohen, SL ;

Chait, BT ;

MacKinnon, R .

SCIENCE, 1998, 280 (5360) :69-77

[6] VIEWING THE KIDNEY THROUGH MICROELECTRODES [J].

FROMTER, E .

AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (05) :F695-F705

[7] Structure of a glycerol-conducting channel and the basis for its selectivity [J].

Fu, DX ;

Libson, A ;

Miercke, LJW ;

Weitzman, C ;

Nollert, P ;

Krucinski, J ;

Stroud, RM .

SCIENCE, 2000, 290 (5491) :481-486

[8] MUTATIONS IN THE K+ CHANNEL SIGNATURE SEQUENCE [J].

HEGINBOTHAM, L ;

LU, Z ;

ABRAMSON, T ;

MACKINNON, R .

BIOPHYSICAL JOURNAL, 1994, 66 (04) :1061-1067

[9] STRUCTURAL ELEMENTS INVOLVED IN SPECIFIC K+ CHANNEL FUNCTIONS [J].

JAN, LY ;

JAN, YN .

ANNUAL REVIEW OF PHYSIOLOGY, 1992, 54 :535-555

[10] GATING KINETICS OF THE CYCLIC-GMP-ACTIVATED CHANNEL OF RETINAL RODS - FLASH-PHOTOLYSIS AND VOLTAGE-JUMP STUDIES [J].

KARPEN, JW ;

ZIMMERMAN, AL ;

STRYER, L ;

BAYLOR, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1287-1291

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