Female genital tract immunization:: Evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation

被引：17

作者：

Crernel, Magali ^{[1
]}

Hamzeh-Cognasse, Hind ^{[1
]}

Genin, Christian ^{[1
]}

Delezay, Olivier ^{[1
]}

机构：

[1] Univ St Etienne, GIMAP, Fac Med, EA 3064, F-42023 St Etienne 2, France

来源：

VACCINE | 2006年 / 24卷 / 29-30期

关键词：

female genital tract; local immunization; candidate mucosal immunoadjuvants;

D O I：

10.1016/j.vaccine.2006.04.044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The female genital tract is an important site. for numerous pathogens entry. Local immunization, generating specific mucosal IgA and systemic IgG, represents an interesting alternative immunization pathway. However, such a vaccine strategy needs mucosal adjuvants to obtain the best immune response. Considering that the immunization process is mainly dependent on the capture and on the transport of the antigen by Langerhans cells, we evaluated potential adjuvant molecules by analysing their effects on the CCL20 secretion by endocervical and exocervical/vaginal epithelial cells as well as on dendritic cell and Langerhans cell maturation. We demonstrated that DC-Chol and Zymosan are the most efficient mucosal candidate immunoadjuvants that generate a strong increase of CCL20 secretion by the two epithelial cell lines and the maturation of dendritic and Langerhans cells, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5744 / 5754

页数：11

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