Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles

被引：441

作者：

Hu, Y ^{[1
]}

Jiang, XQ ^{[1
]}

Ding, Y ^{[1
]}

Ge, HX ^{[1
]}

Yuan, YY ^{[1
]}

Yang, CZ ^{[1
]}

机构：

[1] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Lab Mesoscop Mat, Nanjing 210093, Peoples R China

来源：

BIOMATERIALS | 2002年 / 23卷 / 15期

关键词：

chitosan; poly(acrylic acid); nanoparticles; drug delivery; silk peptide;

D O I：

10.1016/S0142-9612(02)00071-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Chitosan (CS)-poly(acrylic acid) (PAA) complex nanoparticles, which are well dispersed and stable in aqueous solution, have been prepared by template polymerization of acrylic acid (AA) in chitosan Solution. The physicochemical properties of nanoparticles were investigated by using size exclusion chromatography, FT-IR, dynamic light scattering, transmission electron microscope and zeta potential. It was found that the molecular weight of PAA in nanoparticles increased with the increase of molecular weight of CS, indicating that the polymerization of acrylic acid in the chitosan solution was a template polymerization. It was also found that the prepared nanoparticles carried a positive charge and showed the size in the range front 50 to 400 nm. The surface structure and zeta potential of nanoparticles can be controlled by different preparation processes. The experiment of in vitro silk peptide (SP) release showed that these nanoparticles provided a continuous release of the entrapped SP for 10 days, and the release behavior was influenced by the pH value of the medium. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3193 / 3201

页数：9

共 35 条

[1] A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of chitosan [J].