A set of BAC clones spanning the human genome

被引：102

作者：

Krzywinski, M

Bosdet, I

Smailus, D

Chiu, R

Mathewson, C

Wye, N

Barber, S

Brown-John, M

Chan, S

Chand, S

Cloutier, A

Girn, N

Lee, D

Masson, A

Mayo, M

Olson, T

Pandoh, P

Prabhu, AL

Schoenmakers, E

Tsai, M

Albertson, D

Lam, W

Choy, CO

Osoegawa, K

Zhao, SY

de Jong, PJ

Schein, J

Jones, S

Marra, MA ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

[2] Univ Med Ctr Nijmegen, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands

[3] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[4] Childrens Hosp Oakland, BACPAC Resources, Oakland, CA 94609 USA

[5] Inst Gen Res, Rockville, MD 20850 USA

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷 / 12期

关键词：

D O I：

10.1093/nar/gkh700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the human bacterial artificial chromosome (BAC) fingerprint-based physical map, genome sequence assembly and BAC end sequences, we have generated a fingerprint-validated set of 32855 BAC clones spanning the human genome. The clone set provides coverage for at least 98% of the human fingerprint map, 99% of the current assembled sequence and has an effective resolving power of 79 kb. We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease.

引用

页码：3651 / 3660

页数：10

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