Antibody class switching: uncoupling S region accessibility from transcription

被引:14
作者
Kaminski, DA [1 ]
Stavnezer, J [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Immunol & Virol, Worcester, MA 01655 USA
关键词
D O I
10.1016/j.tig.2004.06.008
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently, Nambu et al. showed that histone acetylation is induced at switch (S) regions undergoing CSR; however, histone acetylation without accompanying S region transcription is insufficient to attract activation-induced cytidine deaminase (AID), which is required for CSR. They also show that AID can associate with RNA polymerase II. These results support the model that germline transcripts are required to form single-stranded DNA, the AID substrate and further suggest that AID is recruited to S regions by the transcriptional machinery.
引用
收藏
页码:337 / 340
页数:4
相关论文
共 34 条
[1]   S-REGION TRANSCRIPTION PER-SE PROMOTES BASAL IGE CLASS SWITCH RECOMBINATION BUT ADDITIONAL FACTORS REGULATE THE EFFICIENCY OF THE PROCESS [J].
BOTTARO, A ;
LANSFORD, R ;
XU, LX ;
ZHANG, J ;
ROTHMAN, P ;
ALT, FW .
EMBO JOURNAL, 1994, 13 (03) :665-674
[2]   Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase [J].
Bransteitter, R ;
Pham, P ;
Scharff, MD ;
Goodman, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :4102-4107
[3]  
BRAR S, IN PRESS J BIOL CHEM
[4]   Transcription-targeted DNA deamination by the AID antibody diversification enzyme [J].
Chaudhuri, J ;
Tian, M ;
Khuong, C ;
Chua, K ;
Pinaud, E ;
Alt, FW .
NATURE, 2003, 422 (6933) :726-730
[5]   RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination [J].
Daniels, GA ;
Lieber, MR .
NUCLEIC ACIDS RESEARCH, 1995, 23 (24) :5006-5011
[6]   Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase [J].
Di Noia, J ;
Neuberger, MS .
NATURE, 2002, 419 (6902) :43-48
[7]   AID mediates hypermutation by deaminating single stranded DNA [J].
Dickerson, SK ;
Market, E ;
Besmer, E ;
Papavasiliou, EN .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (10) :1291-1296
[8]   Processing of switch transcripts is required for targeting of antibody class switch recombination [J].
Hein, K ;
Lorenz, MGO ;
Siebenkotten, G ;
Petry, K ;
Christine, R ;
Radbruch, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2369-2374
[9]   Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination [J].
Imai, K ;
Slupphaug, G ;
Lee, WI ;
Revy, P ;
Nonoyama, S ;
Catalan, N ;
Yel, L ;
Forveille, M ;
Kavli, B ;
Krokan, HE ;
Ochs, HD ;
Fischer, A ;
Durandy, A .
NATURE IMMUNOLOGY, 2003, 4 (10) :1023-1028
[10]   Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 [J].
Ito, S ;
Nagaoka, H ;
Shinkura, R ;
Begum, N ;
Muramatsu, M ;
Nakata, M ;
Honjo, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) :1975-1980