RETRACTED: Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus (Retracted Article)

被引：362

作者：

Doreau, Agnes ^{[1
,2
,3
]}

Belot, Alexandre ^{[1
,4
,5
]}

Bastid, Jeremy ^{[1
,6
,7
]}

Riche, Benjamin ^{[1
,8
]}

Trescol-Biemont, Marie-Claude ^{[1
,2
,3
]}

Ranchin, Bruno ^{[1
,4
]}

Fabien, Nicole ^{[1
,2
,9
]}

Cochat, Pierre ^{[1
,4
,10
]}

Pouteil-Noble, Claire ^{[1
,11
]}

Trolliet, Pierre ^{[1
,11
]}

Durieu, Isabelle ^{[1
,12
]}

Tebib, Jacques ^{[1
,13
]}

Kassai, Berhouz ^{[1
,14
]}

Ansieau, Stephane ^{[1
,6
,7
]}

Puisieux, Alain ^{[1
,6
,7
]}

Eliaou, Jean-Francois ^{[15
]}

Bonnefoy-Berard, Nathalie ^{[1
,2
,3
]}

机构：

[1] Univ Lyon, Lyon, France

[2] INSERM, U851, F-69008 Lyon, France

[3] Univ Lyon 1, Inst Federatif Rech 128, F-69365 Lyon, France

[4] Hop Femme Mere Enfant, Serv Nephrol & Rhumatol Pediat, Ctr Reference Malad Renales Rares, Bron, France

[5] CNRS, UMR5239, Oullins, France

[6] INSERM, U590, F-69008 Lyon, France

[7] Federat Natl Ctr Lutte Canc, Ctr Leon Berard, Lyon, France

[8] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Biostat, Lyon, France

[9] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Immunol, Lyon, France

[10] INSERM, U820, F-69008 Lyon, France

[11] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Nephrol, Lyon, France

[12] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Med Interne, Lyon, France

[13] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Rhumatol, Lyon, France

[14] Ctr Hosp Univ Lyon, Epidemiol Pharmacol Invest Clin Informat Med Mere, Serv Pharmacol Clin, Hop L Pradel,INSERM,CIC201,UMR 5558, Lyon, France

[15] Univ Montpellier I, Serv Immunol, CHU Montpellier, Fac Med, Montpellier, France

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 07期

关键词：

NF-KAPPA-B; T-HELPER-CELLS; LYMPHOCYTE STIMULATOR; TOLERANCE CHECKPOINTS; RECEPTOR STIMULATION; INDUCED APOPTOSIS; GENE-EXPRESSION; UP-REGULATION; CUTTING EDGE; SURVIVAL;

D O I：

10.1038/ni.1741

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies have suggested involvement of interleukin 17 (IL-17) in autoimmune diseases, although its effect on B cell biology has not been clearly established. Here we demonstrate that IL-17 alone or in combination with B cell-activating factor controlled the survival and proliferation of human B cells and their differentiation into immunoglobulin-secreting cells. This effect was mediated mainly through the nuclear factor-kappa B-regulated transcription factor Twist-1. In support of the relevance of our observations and the potential involvement of IL-17 in B cell biology, we found that the serum of patients with systemic lupus erythematosus had higher concentrations of IL-17 than did the serum of healthy people and that IL-17 abundance correlated with the disease severity of systemic lupus erythematosus.

引用

页码：778 / U142

页数：10

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