Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes

被引：50

作者：

Alcaro, S

Ventura, CA

Paolino, D

Battaglia, D

Ortuso, F

Cattel, L

Puglisi, G

Fresta, M

机构：

[1] Univ Magna Graecia Catanzaro, Dept Pharmacobiol Sci, I-88021 Roccelletta Di Borgia, CZ, Italy

[2] Univ Messina, Dept Pharmacochem, I-98168 Messina, Italy

[3] Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy

[4] Univ Turin, Dept Drug Sci & Technol, I-10125 Turin, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00217-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement, with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1637 / 1641

页数：5

共 20 条

[1] Alcaro S, 2000, J COMPUT CHEM, V21, P515, DOI 10.1002/(SICI)1096-987X(200005)21:7<515::AID-JCC2>3.0.CO
[2] 2-5
[3] Cabral-Marques H.M., 1990, INT J PHARMACEUT, V63, P259
[4] In vitro modulation of doxorubicin and docetaxel antitumoral activity by methyl-β-cyclodextrin
Grosse, PY
Bressolle, F
Pinguet, F
[J]. EUROPEAN JOURNAL OF CANCER, 1998, 34 (01) : 168 - 174
[5] THERMAL-BEHAVIOR OF GROUND MIXTURES OF HEPTAKIS (2,6-DI-O-METHYL)-BETA-CYCLODEXTRIN AND BENZOIC-ACID
HANAWA, T
YONEMOCHI, E
OGUCHI, T
NAKAI, Y
YAMAMOTO, K
[J]. JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, 1993, 15 (01): : 91 - 101
[6] Higuchi T., 1965, Interscience, New York, V4, P117
[7] HISTAMINE-RELEASE IN DOGS BY CREMOPHOR-EL AND ITS DERIVATIVES - OXETHYLATED OLEIC-ACID IS MOST EFFECTIVE CONSTITUENT
LORENZ, W
REIMANN, HJ
SCHMAL, A
DORMANN, P
SCHWARZ, B
NEUGEBAUER, E
DOENICKE, A
[J]. AGENTS AND ACTIONS, 1977, 7 (01): : 63 - 67
[8] Refined structure of αβ-tubulin at 3.5 A resolution
Löwe, J
Li, H
Downing, KH
Nogales, E
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 313 (05) : 1045 - 1057
[9] CRYSTAL AND MOLECULAR-STRUCTURE OF PACLITAXEL (TAXOL)
MASTROPAOLO, D
CAMERMAN, A
LUO, YG
BRAYER, GD
CAMERMAN, N
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) : 6920 - 6924
[10] MACROMODEL - AN INTEGRATED SOFTWARE SYSTEM FOR MODELING ORGANIC AND BIOORGANIC MOLECULES USING MOLECULAR MECHANICS
MOHAMADI, F
RICHARDS, NGJ
GUIDA, WC
LISKAMP, R
LIPTON, M
CAUFIELD, C
CHANG, G
HENDRICKSON, T
STILL, WC
[J]. JOURNAL OF COMPUTATIONAL CHEMISTRY, 1990, 11 (04) : 440 - 467

← 1 2 →