Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes

被引:50
作者
Alcaro, S
Ventura, CA
Paolino, D
Battaglia, D
Ortuso, F
Cattel, L
Puglisi, G
Fresta, M
机构
[1] Univ Magna Graecia Catanzaro, Dept Pharmacobiol Sci, I-88021 Roccelletta Di Borgia, CZ, Italy
[2] Univ Messina, Dept Pharmacochem, I-98168 Messina, Italy
[3] Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy
[4] Univ Turin, Dept Drug Sci & Technol, I-10125 Turin, Italy
关键词
D O I
10.1016/S0960-894X(02)00217-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement, with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:1637 / 1641
页数:5
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