Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis

被引：83

作者：

LeCouter, J ^{[1
]}

Lin, R ^{[1
]}

Ferrara, N ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 09期

关键词：

D O I：

10.1038/nm0902-913

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diversity in growth and morphological characteristics among endothelial cells in different normal tissues and tumors has been long recognized. Yet there has been no clear molecular explanation for such diversity at the level of vascular endothelial growth factor A (VEGF-A) and other established regulators of angiogenesis that are expressed widely and show little tissue selectivity in their angiogenic properties. Endocrine gland-derived VEGF represent the first example of a tissue-specific angiogenic factor, likely to be followed by others.

引用

页码：913 / 917

页数：5

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