Architecture of the SARS coronavirus prefusion spike

被引：188

作者：

Beniac, Daniel R.

Andonov, Anton

Grudeski, Elsie

Booth, Tim F.

机构：

[1] Publ Hlth Agcy Canada, Viral Dis Div, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 08期

关键词：

D O I：

10.1038/nsmb1123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.

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页码：751 / 752

页数：2

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