A novel entry to pyrido[4,3-b]carbazoles:: An efficient synthesis of ellipticine

被引：74

作者：

Ishikura, M ^{[1
]}

Hino, A ^{[1
]}

Yaginuma, T ^{[1
]}

Agata, I ^{[1
]}

Katagiri, N ^{[1
]}

机构：

[1] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 02期

关键词：

indolylborate; pyrido[4,3-b]carbazole; cross-coupling reaction; ellipticine;

D O I：

10.1016/S0040-4020(99)01016-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium catalyzed tandem cyclization-cross-coupling reaction of indolylborate (2) with vinyl bromide (9) was developed for the preparation of pyrido[4,3-b]carbazole as a key reaction. The cross-coupling reaction of 2a provided hexatriene (10), and then cyclization of 10 to pyrido[4,3-b]carbazole (12) was effected with irradiation or Lewis acid. Using indolylborate (2c) for the cross-coupling reaction, a novel construction of ellipticine was attained through similar reaction sequences. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：193 / 207

页数：15

共 36 条

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