Design and application of HSV vectors for neuroprotection

被引：37

作者：

Fink, DJ

DeLuca, NA

Yamada, M

Wolfe, DP

Glorioso, JC

机构：

[1] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[3] VA Pittsburgh Healthcare Syst, GRECC, Pittsburgh, PA USA

[4] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

来源：

GENE THERAPY | 2000年 / 7卷 / 02期

关键词：

herpes simplex; gene transfer; neurodegenerative disease; nerve growth factor;

D O I：

10.1038/sj.gt.3301118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herpes simplex virus has been extensively genetically modified for gene transfer to nerve and other tissues, to create vectors that are devoid of viral gene expression and toxicity. Recombinant vectors have been engineered to express genes which protect neurons against toxic insults resulting in cell death, including nerve growth factor (NGF) and anti-apopiotic genes (eg bcl-2). This review describes experiments using HSV vectors expressing these gene products and their potential protective role in ameliorating neurodegenerative processes in animal model systems.

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收藏

页码：115 / 119

页数：5

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