In-vitro activity of arbekacin alone and in combination with vancomycin against gentamicin- and methicillin-resistant Staphylococcus aureus

被引：19

作者：

You, I

Kariyama, R

Zervos, MJ

Kumon, H

Chow, JW ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Div Infect Dis,Res & Med Serv, John D Dingell Dept Vet Affairs Med Ctr, Detroit, MI 48201 USA

[2] Okayama Univ, Sch Med, Dept Urol, Okayama 700, Japan

[3] William Beaumont Hosp, Royal Oak, MI 48073 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2000年 / 36卷 / 01期

关键词：

D O I：

10.1016/S0732-8893(99)00104-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In-vitro susceptibility studies were performed on 99 clinical Staphylococcus aureus isolates. A total of 68 of 73 methicillin-resistant S. aureus and 2 of 26 methicillin-susceptible S. aureus were gentamicin-resistant (gentamicin MIC range 16 to 1,024 mu g/mL). All 70 gentamicin-resistant isolates contained the aac(6')-Ie-aph(2 ")-Ia aminoglycoside resistance gene, and none possessed the aph(2 ")-Ic or aph(2 ")-Id aminoglycoside resistance genes. The arbekacin MIC for the 70 gentamicin-resistant isolates ranged from 0.25 to 4 mu g/mL. The combination of arbekacin plus vancomycin produced synergistic killing against 12 of 13 gentamicin-resistant MRSA isolates. The combination of gentamicin plus vancomycin produced synergistic killing against 7 of the same 13 isolates. Arbekacin may prove useful when used in combination with vancomycin in treating infections caused by gentamicin-resistant MRSA. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：37 / 41

页数：5

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