The determination of a diffusional pathlength through the stratum corneum

被引：14

作者：

Bunge, AL

Guy, RH

Hadgraft, J ^{[1
]}

机构：

[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[2] Colorado Sch Mines, Dept Chem Engn & Petr Refining, Golden, CO 80401 USA

[3] Ctr Interuniv Rech & Enseignement Pharmapeptides, F-74166 Archamps, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 188卷 / 01期

关键词：

diffusional pathlength; human stratum corneum;

D O I：

10.1016/S0378-5173(99)00161-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：121 / 124

页数：4

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