Tolevamer Is Not Efficacious in the Neutralization of Cytotoxin in a Human Gut Model of Clostridium difficile Infection

被引：33

作者：

Baines, Simon D. ^{[2
]}

Freeman, Jane ^{[1
]}

Wilcox, Mark H. ^{[1
,2
]}

机构：

[1] Gen Infirm, Dept Microbiol, Old Med Sch, Leeds LS1 3EX, W Yorkshire, England

[2] Univ Leeds, Dept Microbiol, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期

关键词：

TOXIN PRODUCTION; PSEUDOMEMBRANOUS COLITIS; IN-VITRO; VANCOMYCIN; METRONIDAZOLE; DIARRHEA; POLYMER; PROLIFERATION; RIBOTYPE-027; TEICOPLANIN;

D O I：

10.1128/AAC.01085-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.

引用

页码：2202 / 2204

页数：3

共 29 条

[1] Comparison of clinical and microbiological response to treatment of Clostridium difficile associated disease with metronidazole and vancomycin [J].

Al-Nassir, Wafa N. ;

Sethi, Ajay K. ;

Nerandzic, Michelle M. ;

Bobulsky, Greg S. ;

Jump, Robin L. P. ;

Donskey, Curtis J. .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (01) :56-62

[2]

[Anonymous], 47 INT C ANT AG CHEM

[3] Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model [J].

Baines, SD ;

Freeman, J ;

Wilcox, MH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (06) :974-982

[4] Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model [J].

Baines, Simon D. ;

O'Connor, Rachael ;

Saxton, Katie ;

Freeman, Jane ;

Wilcox, Mark H. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) :1078-1085

[5] Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model [J].

Baines, Simon D. ;

Saxton, Katie ;

Freeman, Jane ;

Wilcox, Mark H. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (05) :1062-1065

[6] AN INVITRO MODEL OF COLONIZATION RESISTANCE TO CLOSTRIDIUM-DIFFICILE INFECTION [J].

BORRIELLO, SP ;

BARCLAY, FE .

JOURNAL OF MEDICAL MICROBIOLOGY, 1986, 21 (04) :299-309

[7]

Bouza E, 2008, 18 EUR C CLIN MICR I

[8] Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea [J].

Braunlin, W ;

Xu, QW ;

Hook, P ;

Fitzpatrick, R ;

Klinger, JD ;

Burrier, R ;

Kurtz, CB .

BIOPHYSICAL JOURNAL, 2004, 87 (01) :534-539

[9] FECAL TOXIN AND SEVERITY OF ANTIBIOTIC-ASSOCIATED PSEUDOMEMBRANOUS COLITIS [J].

BURDON, DW ;

GEORGE, RH ;

MOGG, GAG ;

ARABI, Y ;

THOMPSON, H ;

JOHNSON, M ;

ALEXANDERWILLIAMS, J ;

KEIGHLEY, MRB .

JOURNAL OF CLINICAL PATHOLOGY, 1981, 34 (05) :548-551

[10] PROSPECTIVE-STUDY OF ORAL TEICOPLANIN VERSUS ORAL VANCOMYCIN FOR THERAPY OF PSEUDOMEMBRANOUS COLITIS AND CLOSTRIDIUM-DIFFICILE-ASSOCIATED DIARRHEA [J].

DELALLA, F ;

NICOLIN, R ;

RINALDI, E ;

SCARPELLINI, P ;

RIGOLI, R ;

MANFRIN, V ;

TRAMARIN, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (10) :2192-2196

← 1 2 3 →