Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

被引：795

作者：

Semenza, Gregg L. ^{[1
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机构：

[1] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,McKusick Nathans Inst Genet Med, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

来源：

PHYSIOLOGY | 2009年 / 24卷 / 02期

关键词：

CHRONIC INTERMITTENT HYPOXIA; MICE PARTIALLY DEFICIENT; LINDAU TUMOR-SUPPRESSOR; GENE-EXPRESSION; CAROTID-BODY; FACTOR-I; TRANSCRIPTIONAL REGULATION; HIF-1-ALPHA EXPRESSION; PROLYL HYDROXYLASES; IRON HOMEOSTASIS;

D O I：

10.1152/physiol.00045.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Metazoan organisms are dependent on a continuous supply of O-2 for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca2+ signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis, and metabolic reprogramming. In each case, HIF-1 regulates the expression of multiple genes encoding key components of the response pathway. HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively.

引用

收藏

页码：97 / 106

页数：10

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