Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice

被引：58

作者：

Goodwin, David ^{[1
]}

Rosenzweig, Barry ^{[1
]}

Zhang, Jun ^{[1
]}

Xu, Lin ^{[1
]}

Stewart, Sharron ^{[1
]}

Thompson, Karol ^{[1
]}

Rouse, Rodney ^{[1
]}

机构：

[1] US FDA, Div Appl Regulatory Sci, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA

来源：

BIOMARKERS | 2014年 / 19卷 / 06期

关键词：

Caerulein; microRNA; pancreas; pancreatitis; CIRCULATING MICRORNAS; SERUM AMYLASE; ACINAR-CELL; ARGININE; MARKERS; LIPASE; ULTRASTRUCTURE; ISOAMYLASE; CERULEIN; MODEL;

D O I：

10.3109/1354750X.2014.944217

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Mild injury of the exocrine pancreas is often asymptomatic and can be under-or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exocrine pancreas injury in rodent models of acute pancreatitis induced by caerulein, L-arginine, and pancreatic duct ligation. Both microRNAs showed time-and dose-relevant responses to pancreatic injury and wider dynamic ranges of response than serum amylase or lipase. Pancreas-selective microRNAs were found to be relatively sensitive serum biomarkers of pancreatic injury in rodents with potentially greater specificity than the current standard assays.

引用

页码：517 / 529

页数：13

共 44 条

[1]

Prospective Evaluation of Subjects With Chronic Asymptomatic Pancreatic Hyperenzymemia [J].

Amodio, Antonio ;

Manfredi, Riccardo ;

Katsotourchi, Anna Maria ;

Gabbrielli, Armando ;

Benini, Luigi ;

Mucelli, Roberto Pozzi ;

Vantini, Italo ;

Frulloni, Luca .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (07) :1089-1095

[2]

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes [J].

Baskerville, S ;

Bartel, DP .

RNA, 2005, 11 (03) :241-247

[3]

Evaluating Second-Line Treatment Options for Type 2 Diabetes: Focus on Secondary Effects of GLP-1 Agonists and DPP-4 Inhibitors [J].

Boland, Cassie L. ;

DeGeeter, Michelle ;

Nuzum, Donald S. ;

Tzefos, Maria .

ANNALS OF PHARMACOTHERAPY, 2013, 47 (04) :490-505

[4]

ULTRASTRUCTURE OF EARLY DEVELOPMENT OF ACUTE-PANCREATITIS IN THE RAT [J].

BRACKETT, KA ;

CROCKET, A ;

JOFFE, SN .

DIGESTIVE DISEASES AND SCIENCES, 1983, 28 (01) :74-84

[5]

MicroRNA functions [J].

Bushati, Natascha ;

Cohen, Stephen M. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 :175-205

[6]

Acute pancreatitis - Animal models and recent advances in basic research [J].

Chan, Yuk Cheung ;

Leung, Po Sing .

PANCREAS, 2007, 34 (01) :1-14

[7]

ACUTE-PANCREATITIS AND NORMOAMYLASEMIA - NOT AN UNCOMMON COMBINATION [J].

CLAVIEN, PA ;

ROBERT, J ;

MEYER, P ;

BORST, F ;

HAUSER, H ;

HERRMANN, F ;

DUNAND, V ;

ROHNER, A .

ANNALS OF SURGERY, 1989, 210 (05) :614-620

[8]

Dawra R., 2012, PANCREAPEDIA EXOCRIN, DOI [10.3998/panc.2012.6, DOI 10.3998/PANC.2012.6]

[9]

SERUM AMYLASE, ISOAMYLASE AND LIPASE IN ACUTE ALCOHOLISM [J].

DEMDEN, MC ;

WONG, L ;

HARRIS, OD .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1984, 14 (06) :819-821

[10]

Exenatide (Exendin-4)-induced pancreatitis - A case report [J].

Denker, PS ;

Dimarco, PE .

DIABETES CARE, 2006, 29 (02) :471-471

← 1 2 3 4 5 →