Central diabetes insipidus preceding acute myeloid leukemia with t(3;12)(q26;p12)

被引：18

作者：

Nieboer, P

Vellenga, E

Adriaanse, R

van de Loosdrecht, AA

机构：

[1] Univ Groningen Hosp, Dept Internal Med, Div Hematol, NL-9700 RB Groningen, Netherlands

[2] Hosp De Tjongerschans, Dept Internal Med, Div Endocrinol, NL-8441 PW Heerenveen, Netherlands

来源：

NETHERLANDS JOURNAL OF MEDICINE | 2000年 / 56卷 / 02期

关键词：

acute myeloid leukemia; central diabetes insipidus; t(3,12)(q26,p12);

D O I：

10.1016/S0300-2977(99)00110-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 52-year-old woman presented with polyuria and polydipsia. ii diagnosis of central diabetes insipidus (DI) was made, which turned out to be the first sign of acute myeloid leukemia (AML). Cytogenetic analysis revealed a balanced translocation between chromosome 3 and 12 t(3;12)(q26;p12). The patient was treated with standard induction chemotherapy and vasopressin. Before consolidation chemotherapy could be administered, deep venous thrombosis was diagnosed and leukemia relapsed. Rescue chemotherapy was started. This is the first report of an association between AML with t(3;12) and DI. Its possible pathogenesis is discussed with a review of the literature. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 47

页数：3

共 16 条

[1] 3 NEW CASES OF CHROMOSOME-3 REARRANGEMENT IN BAND-Q21 AND BAND-Q26 WITH ABNORMAL THROMBOPOIESIS BRING FURTHER EVIDENCE TO THE EXISTENCE OF A 3Q21Q26-SYNDROME [J].