Minocycline delays disease onset and mortality in a transgenic model of ALS

被引:236
作者
Van Den Bosch, L [1 ]
Tilkin, P [1 ]
Lemmens, G [1 ]
Robberecht, W [1 ]
机构
[1] Neurobiol Lab, B-3000 Louvain, Belgium
关键词
amyotrophic lateral sclerosis; inflammation; microglia; neurodegeneration;
D O I
10.1097/00001756-200206120-00018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Microglial activation is thought to contribute to the progression of selective motor neuron death during amyotrophic lateral sclerosis (ALS). As minocycline has been shown to inhibit microglial activation, the therapeutic efficacy of this tetracycline derivative in the G93A mice model for familial ALS was tested. This drug with proven safety delayed disease onset and dose-dependently extended the survival of the G93A mice. At 120 days of age, minocycline protected mice from loss of motor neurons and from vacuolization. These results demonstrate that interference with immuno-inflammatory responses has a beneficial effect in the ALS mice model, suggesting this to be a potential new strategy to treat ALS.
引用
收藏
页码:1067 / 1070
页数:4
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