Investigation of Inflammatory and Hemostatic Parameters in Female Patients Undergoing Total Knee Arthroplasty Surgery

被引：21

作者：

Alturfan, A. Ata ^{[1
]}

Eralp, Levent ^{[2
]}

Emekli, Nesrin ^{[3
]}

机构：

[1] Istanbul Univ, Cerrahpasa Med Fac, Vocat Sch, Hlth Ser, Istanbul, Turkey

[2] Istanbul Univ, Fac Med, Dept Orthopaed & Traumatol, Istanbul, Turkey

[3] Marmara Univ, Sch Dent, Dept Biochem, Istanbul, Turkey

来源：

INFLAMMATION | 2008年 / 31卷 / 06期

关键词：

osteoarthritis; inflammation; coagulation; galectin-3; tissue factor;

D O I：

10.1007/s10753-008-9093-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tendency to hypercoagulation is a common phenomenon in primary osteoarthritis patients (POA) undergoing total knee arthroplasty (TKA) surgery, but the clinical implications of this condition are not clear. Therefore we aimed to evaluate the inflammatory and coagulation parameters in the patient group and find a possible explanation for the tendency to hypercoagulation occurring in plasma and synovia of inflamed joints. Of the evaluated factors involved in inflammation and coagulation, galectin-3, C reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, FVIIa:C, FXII:C, and platelet count increased, whereas tissue factor (TF) activity in synovia, PT, APTT and FVII:C in plasma and synovia were decreased. In conclusion, activation of inflammation and tendency to hypercoagulation is observed in preoperative plasma and synovia of patients undergoing TKA surgery.

引用

页码：414 / 421

页数：8

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