Mesenchymal stromal cell therapy for liver diseases

被引：198

作者：

Alfaifi, Mohammed ^{[1
,2
]}

Eom, Young Woo ^{[3
,4
]}

Newsome, Philip N. ^{[1
,5
,6
]}

Baik, Soon Koo ^{[3
,4
]}

机构：

[1] Univ Birmingham, Inst Immunol & Immunotherapy, Ctr Liver Res, Birmingham, W Midlands, England

[2] King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Abha, Saudi Arabia

[3] Yonsei Univ, Wonju Coll Med, Cell Therapy & Tissue Engn Ctr, Wonju, South Korea

[4] Yonsei Univ, Wonju Coll Med, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea

[5] Univ Hosp Birmingham NHS Fdn Trust, Natl Inst Hlth, Res Biomed Res Ctr, Birmingham, W Midlands, England

[6] Univ Birmingham, Birmingham, W Midlands, England

来源：

JOURNAL OF HEPATOLOGY | 2018年 / 68卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Mesenchymal stromal cell; Liver disease; Enrichment; Priming; Genetic engineering; HUMAN BONE-MARROW; UMBILICAL-CORD BLOOD; PRIMARY BILIARY-CIRRHOSIS; HEPATIC STELLATE CELLS; HEPATOCYTE-LIKE CELLS; REGULATORY T-CELLS; STEM-CELLS; IN-VITRO; ADIPOSE-TISSUE; MEDIATED IMMUNOSUPPRESSION;

D O I：

10.1016/j.jhep.2018.01.030

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The therapeutic potential of mesenchymal stromal cells (MSCs) in the treatment of liver fibrosis is predominantly based on their immunosuppressive properties, and their ability to secrete various trophic factors. This potential has been investigated in clinical and preclinical studies. Although the therapeutic mechanisms of MSC transplantation are still not fully characterised, accumulating evidence has revealed that various trophic factors secreted by MSCs play key therapeutic roles in regeneration by alleviating inflammation, apoptosis, and fibrosis as well as stimulating angiogenesis and tissue regeneration in damaged liver. In this review, we summarise the safety, efficacy, potential transplantation routes and therapeutic effects of MSCs in patients with liver fibrosis. We also discuss some of the key strategies to enhance the functionality of MSCs, which include sorting and/or priming with factors such as cytokines, as well as genetic engineering. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：1272 / 1285

页数：14

共 154 条

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