Downstream Carcinogenesis Signaling Pathways by Green Tea Polyphenols: A Translational Perspective of Chemoprevention and Treatment for Cancers

被引：31

作者：

Hu, Guohua ^{[1
]}

Zhang, Lei ^{[1
]}

Rong, Yefei ^{[1
]}

Ni, Xiaoling ^{[1
]}

Sun, Yihong ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China

来源：

CURRENT DRUG METABOLISM | 2014年 / 15卷 / 01期

关键词：

Cancer; chemoprevention; green tea; polyphenols; treatment; NF-KAPPA-B; (-)-EPIGALLOCATECHIN-3-GALLATE INDUCES APOPTOSIS; HEPATOCYTE GROWTH-FACTOR; GALLATE INHIBITS GROWTH; PROSTATE-CANCER; PROTEIN-KINASE; EPIGALLOCATECHIN GALLATE; IN-VITRO; CELL-PROLIFERATION; COLORECTAL-CANCER;

D O I：

10.2174/1389200214666131211155613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Green tea is one of the most popular beverages around the world. For several decades, numerous epidemiological, preclinical and clinical studies have demonstrated that green tea polyphenols (GTPs), especiallyepigallocatechin-3-gallate (EGCG) have cancer-preventing effects on various cancers. In this review, we present inhibition of carcinogenesis in different animal models by GTPs or EGCG, including prostate cancer, bladder cancer, breast cancer, intestinal cancer, colon cancer, gastric cancer, lung cancer, oral cancer and skin cancer. In vitro studies showed that GTPs/EGCG potently induces apoptosis, cell cycle arrest and suppresses metastasis in tumor cells but not in their normal cell counterparts. The molecular mechanisms of these activities are discussed in detail to elucidate GTPs/EGCG downstream carcinogenesis signaling pathways and their values of perspective of chemoprevention and treatment for cancers.

引用

页码：14 / 22

页数：9

共 117 条

[1]

Effective Prostate Cancer Chemopreventive Intervention with Green Tea Polyphenols in the TRAMP Model Depends on the Stage of the Disease [J].