Progressive loss of cardiac sympathetic innervation in Parkinson's disease

被引：72

作者：

Li, ST ^{[1
]}

Dendi, R ^{[1
]}

Holmes, C ^{[1
]}

Goldstein, DS ^{[1
]}

机构：

[1] NINDS, Clin Neurocardiol Sect, NIH, Bethesda, MD 20892 USA

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 02期

关键词：

D O I：

10.1002/ana.10236

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6-[F-18]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6-[F-18]fluorodopamine-derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism.

引用

页码：220 / 223

页数：4

共 15 条

[1] Impaired cardiac uptake of meta[123I]iodobenzylguanidine in Parkinson's disease with autonomic failure [J].

Braune, S ;

Reinhardt, M ;

Bathmann, J ;

Krause, T ;

Lehmann, M ;

Lucking, CH .

ACTA NEUROLOGICA SCANDINAVICA, 1998, 97 (05) :307-314

[2] Cardiac uptake of [123I]MIBG separates Parkinson's disease from multiple system atrophy [J].

Braune, S ;

Reinhardt, M ;

Schnitzer, R ;

Riedel, A ;

Lücking, CH .

NEUROLOGY, 1999, 53 (05) :1020-1025

[3] Differentiation of Parkinson's disease and multiple system atrophy in early disease stages by means of I-123-MIBG-SPECT [J].

Druschky, A ;

Hilz, MJ ;

Platsch, G ;

Radespiel-Tröger, M ;

Druschky, K ;

Kuwert, T ;

Neundörfer, B .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2000, 175 (01) :3-12

[4] POSITRON EMISSION TOMOGRAPHIC IMAGING OF CARDIAC SYMPATHETIC INNERVATION USING 6-[F-18]FLUORODOPAMINE - INITIAL FINDINGS IN HUMANS [J].

GOLDSTEIN, DS ;

EISENHOFER, G ;

DUNN, BB ;

ARMANDO, I ;

LENDERS, J ;

GROSSMAN, E ;

HOLMES, C ;

KIRK, KL ;

BACHARACH, S ;

ADAMS, R ;

HERSCOVITCH, P ;

KOPIN, IJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1993, 22 (07) :1961-1971

[5] Cardiac sympathetic denervation in Parkinson disease [J].

Goldstein, DS ;

Holmes, C ;

Li, ST ;

Bruce, S ;

Metman, LV ;

Cannon, RO .

ANNALS OF INTERNAL MEDICINE, 2000, 133 (05) :338-347

[6] 123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease [J].

Orimo, S ;

Ozawa, E ;

Nakade, S ;

Sugimoto, T ;

Mizusawa, H .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 67 (02) :189-194

[7] The natural history of Parkinson's disease [J].

Poewe, WH ;

Wenning, GK .

ANNALS OF NEUROLOGY, 1998, 44 (03) :S1-S9

[8] Scintigraphic differentiation between two forms of primary dysautonomia early after onset of autonomic dysfunction:: value of cardiac and pulmonary iodine-123 MIBG uptake [J].

Reinhardt, MJ ;

Jüngling, FD ;

Krause, TM ;

Braune, S .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (05) :595-600

[9]

Satoh A, 1999, J NUCL MED, V40, P371

[10]

Satoh A, 1997, Nihon Rinsho, V55, P202

← 1 2 →