Methodological issues in the assessment of skin microvascular endothelial function in humans

被引：382

作者：

Cracowski, Jean-Luc ^{[1
]}

Minson, Christopher T.

Salvat-Melis, Muriel

Halliwill, John R.

机构：

[1] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA

[2] Grenoble Med Sch, INSERM, ESPRI, HP2 Lab,EA 3745, F-38043 Grenoble 09, France

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 09期

关键词：

D O I：

10.1016/j.tips.2006.07.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The study of microvascular function can be performed in humans using laser Doppler flowmetry of the skin. This technology lends itself to a wide range of applications for studying the endothelial function of skin blood vessels. We review the advantages and limitations of postocclusive hyperemia, local thermal hyperemia, acetylcholine iontophoresis, flowmotion and association with microdialysis as tools with which to investigate skin microvascular endothelial function in humans. Post-occlusive hyperemia, thermal hyperemia and acetylcholine iontophoresis provide integrated indexes of microvascular function rather than specific endothelial markers. However, they are valuable tools and can be used as surrogate endpoints in clinical trials in which the assessment of microvascular function in humans is required.

引用

页码：503 / 508

页数：6

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