Preparation and characterization of a new artemisinin-derived dimer

被引：19

作者：

Galal, AM

Ahmad, MS

ElFeraly, FS ^{[1
]}

McPhail, AT

机构：

[1] KING SAUD UNIV, COLL PHARM, DEPT PHARMACOGNOSY, RIYADH 11451, SAUDI ARABIA

[2] DUKE UNIV, PAUL M GROSS CHEM LAB, DEPT CHEM, DURHAM, NC 27708 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 10期

关键词：

ANTIMALARIAL ARTEETHER;

D O I：

10.1021/np960211a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new dimer (1) that is likely to be a reduction metabolite of arteether (2), the potent antimalarial agent, was prepared from deoxydihydroartemisinin (3). The identity of 1 was established from spectral data and was confirmed by X-ray crystallographic analysis. In addition, the stereochemistry of the related, previously reported dimer (4), is now more clearly defined, based on revising its X-ray crystallographic data.

引用

页码：917 / 920

页数：4

共 9 条

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[7] MICROBIAL AND MAMMALIAN METABOLISM STUDIES OF THE SEMISYNTHETIC ANTIMALARIAL, ANHYDRODIHYDROARTEMISININ
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