Endoplasmic Reticulum Stress: Another Link Between Obesity and Insulin Resistance/Inflammation?

被引:66
作者
Boden, Guenther [1 ]
机构
[1] Temple Univ, Sch Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19122 USA
关键词
FREE FATTY-ACIDS;
D O I
10.2337/db08-1746
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:518 / 519
页数:2
相关论文
共 13 条
[1]   Obesity and Free Fatty Acids [J].
Boden, Guenther .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2008, 37 (03) :635-+
[2]   Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals [J].
Boden, Guenther ;
Duan, Xanbao ;
Homko, Carol ;
Molina, Ezequiel J. ;
Song, WeiWei ;
Perez, Oscar ;
Cheung, Peter ;
Merali, Salim .
DIABETES, 2008, 57 (09) :2438-2444
[3]   Medical consequences of obesity [J].
Bray, GA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2583-2589
[4]   Adipocyte stress: the endoplasmic reticulum and metabolic disease [J].
Gregor, Margaret F. ;
Hotamisligil, Goekhan S. .
JOURNAL OF LIPID RESEARCH, 2007, 48 (09) :1905-1914
[5]   Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss [J].
Gregor, Margaret F. ;
Yang, Ling ;
Fabbrini, Elisa ;
Mohammed, B. Selma ;
Eagon, J. Christopher ;
Hotamisligil, Goekhan S. ;
Klein, Samuel .
DIABETES, 2009, 58 (03) :693-700
[6]   A central role for JNK in obesity and insulin resistance [J].
Hirosumi, J ;
Tuncman, G ;
Chang, LF ;
Görgün, CZ ;
Uysal, KT ;
Maeda, K ;
Karin, M ;
Hotamisligil, GS .
NATURE, 2002, 420 (6913) :333-336
[7]   Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α [J].
Itani, SI ;
Ruderman, NB ;
Schmieder, F ;
Boden, G .
DIABETES, 2002, 51 (07) :2005-2011
[8]   Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells [J].
Lai, Elida ;
Bikopoulos, George ;
Wheeler, Michael B. ;
Rozakis-Adcock, Maria ;
Volchuk, Allen .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (03) :E540-E550
[9]   Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects [J].
Santomauro, ATMG ;
Boden, G ;
Silva, MER ;
Rocha, DM ;
Santos, RF ;
Ursich, MJM ;
Strassmann, PG ;
Wajchenberg, BL .
DIABETES, 1999, 48 (09) :1836-1841
[10]   The mammalian unfolded protein response [J].
Schröder, M ;
Kaufman, RJ .
ANNUAL REVIEW OF BIOCHEMISTRY, 2005, 74 :739-789