Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro

被引：80

作者：

Colston, KW ^{[1
]}

James, SY ^{[1
]}

OforiKuragu, EA ^{[1
]}

Binderup, L ^{[1
]}

Grant, AG ^{[1
]}

机构：

[1] LEO PHARMACEUT PROD,DK-2750 BALLERUP,DENMARK

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 08期

关键词：

pancreatic carcinoma; vitamin D; growth inhibition;

D O I：

10.1038/bjc.1997.501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D-3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 mu g kg(-1) body weight i.p. thrice weekly for 4-6 weeks. Tumour growth was significantly inhibited in treated animals compared with controls in the absence of hypercalcaemia. These findings may have therapeutic implications in pancreatic cancer.

引用

页码：1017 / 1020

页数：4

共 26 条

[1] A NOVEL VITAMIN-D3 ANALOG, 22-OXA-1,25-DIHYDROXYVITAMIN-D3, INHIBITS THE GROWTH OF HUMAN BREAST-CANCER INVITRO AND INVIVO WITHOUT CAUSING HYPERCALCEMIA [J].