CHANGES IN ANTIOXIDANT STATUS AND BIOCHEMICAL PARAMETERS AFTER ORALLY CADMIUM ADMINISTRATION IN FEMALES RATS

被引：12

作者：

Chater, S. ^{[1
,2
,3
]}

Douki, T. ^{[2
]}

Favier, A. ^{[2
,3
]}

Sakly, M. ^{[1
]}

Abdelmelek, H. ^{[1
]}

机构：

[1] Fac Sci Bizerte, Lab Physiol Integree, Jarzouna 7021, Tunisia

[2] CEA Grenoble, Lab Les Acides Nucle, DRFMC, SCIB, F-38054 Grenoble 9, France

[3] Hop Tronche, Lab Stress Oxydant, Dept Biol Integree, F-38700 Grenoble, France

来源：

ACTA BIOLOGICA HUNGARICA | 2009年 / 60卷 / 01期

关键词：

Cadmium; malondialdehyde; 8-oxodGuo; pregnancy; REGIONAL LIPID-PEROXIDATION; EXPOSURE; LIVER; COPPER; DAMAGE; ZINC; DNA; MECHANISMS; HEMATOLOGY; TOXICITY;

D O I：

10.1556/ABiol.60.2009.1.8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The research was conducted to investigate the toxic effects of cadmium chloride (CdCl2), administered during gestation period on female Wistar rats. Pregnant rats received CdCl2 (20 mg/l, orally) from Day 6 to Day 19 of pregnancy. Results showed that Cd treatment induced a decrease in body weight gain. The relative liver weight increased significantly, with a marked decrease of glycogen and total lipids content. The administration of Cd induced hepatotoxicity as indicated by elevations in plasma alanine aminotransferase (ALT), aspartate aminotransferase and lactate dehydrogenase (LDH) activities (p < 0.05). Treatment with CdCl2 caused a significant (p < 0.05) increase in glucose. A significant increase was observed in the level of MDA and 8-oxodGuo tissues in the cadmium-exposed group compared to the control group (p < 0.05). Results showed that cadmium given to dams led to an oxidative stress and DNA damage in tissues of pregnant rats.

引用

页码：79 / 88

页数：10

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