Functional genomics and the breast cancer problem

被引：15

作者：

Ince, TA ^{[1
]}

Weinberg, RA

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CANCER CELL | 2002年 / 1卷 / 01期

关键词：

D O I：

10.1016/S1535-6108(02)00023-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical treatment of primary breast cancers has been greatly complicated by the inability to accurately predict which tumors will eventually become invasive and metastatic and which will remain localized and indolent. Lacking the ability to discriminate between these two classes of breast cancer patients, oncologists often apply aggressive adjuvant therapy to women in both groups. However, the use of functional genomics analysis has now made it possible to assemble a set of gene markers, the expression of which enables one to predict, with reasonably high accuracy, whether or not the patient will relapse or remain tumor-free five years after initial diagnosis and treatment.

引用

页码：15 / 17

页数：3

共 10 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].

Bittner, M ;

Meitzer, P ;

Chen, Y ;

Jiang, Y ;

Seftor, E ;

Hendrix, M ;

Radmacher, M ;

Simon, R ;

Yakhini, Z ;

Ben-Dor, A ;

Sampas, N ;

Dougherty, E ;

Wang, E ;

Marincola, F ;

Gooden, C ;

Lueders, J ;

Glatfelter, A ;

Pollock, P ;

Carpten, J ;

Gillanders, E ;

Leja, D ;

Dietrich, K ;

Beaudry, C ;

Berens, M ;

Alberts, D ;

Sondak, V ;

Hayward, N ;

Trent, J .

NATURE, 2000, 406 (6795) :536-540

[3]

Bland KI, 1998, CANCER-AM CANCER SOC, V83, P1262, DOI 10.1002/(SICI)1097-0142(19980915)83:6<1262::AID-CNCR28>3.0.CO

[4]

2-2

[5]

Harris J R, 2000, DIS BREAST

[6] Prognostic factors in node-negative breast cancer - A review of studies with sample size more than 200 and follow-up more than 5 years [J].

Mirza, AN ;

Mirza, NQ ;

Vlastos, G ;

Singletary, SE .

ANNALS OF SURGERY, 2002, 235 (01) :10-26

[7] Molecular portraits of human breast tumours [J].

Perou, CM ;

Sorlie, T ;

Eisen, MB ;

van de Rijn, M ;

Jeffrey, SS ;

Rees, CA ;

Pollack, JR ;

Ross, DT ;

Johnsen, H ;

Akslen, LA ;

Fluge, O ;

Pergamenschikov, A ;

Williams, C ;

Zhu, SX ;

Lonning, PE ;

Borresen-Dale, AL ;

Brown, PO ;

Botstein, D .

NATURE, 2000, 406 (6797) :747-752

[8] A gene expression database for the molecular pharmacology of cancer [J].

Scherf, U ;

Ross, DT ;

Waltham, M ;

Smith, LH ;

Lee, JK ;

Tanabe, L ;

Kohn, KW ;

Reinhold, WC ;

Myers, TG ;

Andrews, DT ;

Scudiero, DA ;

Eisen, MB ;

Sausville, EA ;

Pommier, Y ;

Botstein, D ;

Brown, PO ;

Weinstein, JN .

NATURE GENETICS, 2000, 24 (03) :236-244

[9] Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications [J].

Sorlie, T ;

Perou, CM ;

Tibshirani, R ;

Aas, T ;

Geisler, S ;

Johnsen, H ;

Hastie, T ;

Eisen, MB ;

van de Rijn, M ;

Jeffrey, SS ;

Thorsen, T ;

Quist, H ;

Matese, JC ;

Brown, PO ;

Botstein, D ;

Lonning, PE ;

Borresen-Dale, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10869-10874

[10] Gene expression profiling predicts clinical outcome of breast cancer [J].

van't Veer, LJ ;

Dai, HY ;

van de Vijver, MJ ;

He, YDD ;

Hart, AAM ;

Mao, M ;

Peterse, HL ;

van der Kooy, K ;

Marton, MJ ;

Witteveen, AT ;

Schreiber, GJ ;

Kerkhoven, RM ;

Roberts, C ;

Linsley, PS ;

Bernards, R ;

Friend, SH .

NATURE, 2002, 415 (6871) :530-536

← 1 →