Proteinase N-catalysed transesterifications in DMSO-water and DMF-water: preparation of sucrose monomethacrylate

被引：34

作者：

Potier, P ^{[1
]}

Bouchu, A ^{[1
]}

Descotes, G ^{[1
]}

Queneau, Y ^{[1
]}

机构：

[1] Eridania Beghin Say, CEI, Unite Mixte Sucrochim CNRS Beghin Say, UMR 143, F-69603 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 19期

关键词：

sucrose; protease; enzyme; transesterification; methacrylates; water;

D O I：

10.1016/S0040-4039(00)00452-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective acylation of sucrose was catalysed by proteinase N (from Bacillus subtilis) in DMF suspensions, providing 1'-monoesters, and notably, methacryloyl esters. Presence of water up to 7% (vol.) led to faster reactions. Alternatively, a slurry of the enzyme with a minimum volume of DMSO could also be used, despite its ability to denature enzymes. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3597 / 3600

页数：4

共 24 条

[1] ENZYMATIC CATALYSIS AND DYNAMICS IN LOW-WATER ENVIRONMENTS [J].