Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease

被引：46

作者：

Tsai, SJ

Liu, HC

Liu, TY

Wang, YC

Hong, CJ

机构：

[1] Vet Gen Hosp Taipei, Dept Psychiat, Taipei 11217, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Vet Gen Hosp Taipei, Dept Neurol, Taipei 11217, Taiwan

[4] Vet Gen Hosp Taipei, Dept Med Res & Educ, Taipei 11217, Taiwan

来源：

NEUROSCIENCE LETTERS | 1999年 / 276卷 / 02期

关键词：

Alzheimer's disease; association study; polymorphism; serotonin receptor 6 gene;

D O I：

10.1016/S0304-3940(99)00802-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonergic dysfunction has been im plicated in the pathogenesis of Alzheimer's disease (AD). This association study explores whether the serotonin 6 receptor (5-HT6) polymorphism (C267T) is a susceptibility factor for AD. Statistical analysis showed a significant difference in the genotype and gene frequencies between the AD group and the normal controls (P = 0.006; and P = 0.023, respectively). These findings indicate that the 267C allale of the 5-HT6 gene is a risk factor for AD. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：138 / 139

页数：2

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