A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor

被引：22

作者：

Fletcher, JM ^{[1
]}

Hughes, RA ^{[1
]}

机构：

[1] Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 38期

关键词：

disulfide; heterodimer; bicyclic; dimerisation; dipyridyl disulfide; peptide; BDNF;

D O I：

10.1016/j.tetlet.2004.08.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a novel acetamidomethyl to S-pyridinyl exchange that is used for the synthesis of a multi-disulfide-linked and constrained heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor (BDNF). This simple and effective method should be readily transferable to the synthesis of similar disulfide-linked heterodimeric peptides, as well as being of general utility for the synthesis of peptides bearing multiple cystine frameworks. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6999 / 7001

页数：3

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