An acetyl flavonol from Nervilia fordii (Hance) Schltr

被引：43

作者：

Zhou, Guang-Xiong ^{[1
]}

Lu, Chuan-Li ^{[1
]}

Wang, Heng-Shan ^{[2
]}

Yao, Xin-Sheng ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Key Lab Pharmacodynam Constituents Tradit Chinese, Guangzhou 510632, Guangdong, Peoples R China

[2] Guangxi Normal Coll, Coll Chem & Chem Engn, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2009年 / 11卷 / 06期

关键词：

Nervilia fordii (Hance) Schltr; 3-O-acetyl-7-O-methyl kaemferol; NO release; NITRIC-OXIDE;

D O I：

10.1080/10286020902893074

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new acetyl flavonol, named 3-O-acetyl-7-O-methyl kaemferol (1), together with the five known compounds rhamnocitrin (2), rhamnocitrin-3-O-beta-D-glucoside (3), rhamnocitrin-4'-beta-D-glucoside (4), rhamnazin (5), and p-hydroxyl benzoic acid (6) was isolated from Nervilia fordii (Hance) Schltr. The structures of the compounds were determined by spectroscopic analysis. All the compounds were evaluated against nitric oxide (NO) release, based on the production of NO in mice RAW264.7 stimulated by lipopolysaccharide (LPS). This new compound (1) showed potent inhibitory activity against the production of NO in RAW264.7 stimulated by LPS with the IC50 value of 16.79 mu M.

引用

页码：498 / 502

页数：5

共 6 条

[1]

Calixto JB, 2004, PLANTA MED, V70, P93, DOI [10.1055/s-2004-815483, 10.1055/s-2003-45141]

[2]

Phenylpropanoid glycosides from Scrophularia scorodonia:: In vitro anti-inflammatory activity [J].

Díaz, AM ;

Abad, MJ ;

Fernández, L ;

Silván, AM ;

De Santos, J ;

Bermejo, P .

LIFE SCIENCES, 2004, 74 (20) :2515-2526

[3]

A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-α in LPS-activated macrophages [J].

Lee, HJ ;

Kim, NY ;

Jang, MK ;

Son, HJ ;

Kim, KM ;

Sohn, DH ;

Lee, SH ;

Ryu, JH .

PLANTA MEDICA, 1999, 65 (02) :104-108

[4]

Stone William L, 2006, Methods Mol Biol, V315, P245

[5]

Zhen Han-shen, 2007, Zhong Yao Cai, V30, P1095

[6]

ZHU H, 2005, LISHIZHEN MED MAT ME, V6, P1042

← 1 →