Positron Emission Tomography Imaging of Neuroinflammation

被引：28

作者：

Kannan, Sujatha ^{[1
]}

Balakrishnan, Bindu ^{[1
]}

Muzik, Otto ^{[1
,2
]}

Romero, Roberto ^{[3
,4
]}

Chugani, Diane ^{[1
,2
]}

机构：

[1] Wayne State Univ, Sch Med, Carman & Ann Adams Dept Pediat, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Radiol, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Dept Med & Mol Genet, Detroit, MI 48201 USA

[4] NICHHD, Perinatol Res Branch, NIH, US Dept HHS, Bethesda, MD 20892 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2009年 / 24卷 / 09期

关键词：

PET; neuroinflammation; PERIPHERAL BENZODIAZEPINE-RECEPTOR; CEREBRAL WHITE-MATTER; MICROGLIAL ACTIVATION; IN-VIVO; BINDING-SITES; BRAIN-INJURY; PERIVENTRICULAR LEUKOMALACIA; INTRAUTERINE INFLAMMATION; MULTIPLE-SCLEROSIS; AFFINITY BINDING;

D O I：

10.1177/0883073809338063

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Injury to the central nervous system is characterized by localization of activated microglia at the site of injury. The peripheral benzodiazepine receptor expressed on the outer mitochondrial membrane of the activated microglia is a sensitive biomarker for the detection of this neuroinflammatory response to an insult. PK11195, an isoquinoline ligand that specifically binds peripheral benzodiazepine receptor, can be tagged with a positron emitter and used as a tracer for molecular imaging of this receptor in vivo by positron emission tomography (PET). [C-11](B)PK11195 has been used in the imaging of various neuroinflammatory disorders, such as Alzheimer disease and multiple sclerosis. On the basis of our small-animal PET imaging studies using a neonatal rabbit model of maternal inflammation-induced cerebral palsy, we propose that PET imaging using [C-11](R)PK11195 may be a Valuable tool for detecting neuroinflammation in the brain of newborns born to mothers with chorioamnionitis.

引用

页码：1190 / 1199

页数：10

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