Matrix metalloproteinases in cancer:: Prognostic markers and therapeutic targets

被引：541

作者：

Vihinen, P

Kähäri, VM

机构：

[1] Univ Turku, MediCity Res Lab, FIN-20520 Turku, Finland

[2] Univ Turku, Cent Hosp, Dept Radiotherapy & Oncol, FIN-20520 Turku, Finland

[3] Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland

[4] Univ Turku, Cent Hosp, Dept Dermatol, FIN-20520 Turku, Finland

来源：

INTERNATIONAL JOURNAL OF CANCER | 2002年 / 99卷 / 02期

关键词：

matrix metalloproteinase; cancer; invasion; metastasis; prognosis; MMP inhibitor;

D O I：

10.1002/ijc.10329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Degradation of extracellular matrix is crucial for malignant tumour growth, invasion, metastasis and angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs can be detected in tumour tissue or serum of patients with advanced cancer and their role as prognostic indicators in cancer is studied. In addition, therapeutic intervention of tumour growth and invasion based on inhibition of MMP activity is under intensive investigation and several MMP inhibitors are in clinical trials in cancer. In this review, we discuss the current view on the feasibility of MMPs as prognostic markers and as targets for therapeutic intervention in cancer. (C) 2002 Wiley-Liss, Inc.

引用

页码：157 / 166

页数：10

共 167 条

[1]

AHMANN FR, 2001, P AN M AM SOC CLIN, V20, pA174

[2] Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas [J].