Trefoil factor family (TFF) peptides and cancer progression

被引：123

作者：

Emami, S ^{[1
]}

Rodrigues, S

Rodrigue, CM

Le Floch, N

Rivat, C

Attoub, S

Bruyneel, E

Gespach, C

机构：

[1] Hop St Antoine, INSERM, U Signal Transduct & Cellular Funct Diabet & Dige, F-75571 Paris 12, France

[2] Ghent Univ Hosp, Expt Cancerol Lab, B-9000 Ghent, Belgium

来源：

PEPTIDES | 2004年 / 25卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

scattering; invasion; apoptosis; angiogenesis; src; PI3 '-kinase; RhoAGTPase; PLC; COX-1; COX-2; TXA-2-R; EGF-R;

D O I：

10.1016/j.peptides.2003.10.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：885 / 898

页数：14

共 200 条

[1] Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells [J].