Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells

被引：450

作者：

Slowing, Igor I. ^{[1
]}

Wu, Chia-Wen ^{[1
]}

Vivero-Escoto, Juan L. ^{[1
]}

Lin, Victor S. -Y. ^{[1
]}

机构：

[1] Iowa State Univ, US DOE, Ames Lab, Dept Chem, Ames, IA 50011 USA

来源：

SMALL | 2009年 / 5卷 / 01期

基金：

美国国家科学基金会;

关键词：

biocompatibility; drug delivery; hemolysis; red blood cells; silica nanoparticles; RESPONSIVE CONTROLLED-RELEASE; DELIVERY-SYSTEM; DRUG-DELIVERY; STEM-CELLS; PARTICLES; TOXICITY; MOLECULES; MEMBRANE; MICELLES; BINDING;

D O I：

10.1002/smll.200800926

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate the use of mesoporous silica nanoparticles (MSN) for reducing hemolytic activity towards mammalian red blood cells (RBC). The study also investigated the interaction of a commercially available amorphous silica material with RBCs under similar experimental conditions, to compare with the hymolytic properties of other nonporous silica materials. The RBCs were isolated from the freshly obtained EDTA-stabilized rabbit blood by centrifugation and purified by washing with sterile isotonic phosphate saline-buffered solution (PBS). Dilution was performed after purification, to yield a stable suspension of RBCs in PBS. The RBC suspensions were mixed with 1.2 cm3 of PBS suspensions, with various concentrations of amorphous silica or MSN. The investigations revealed absence of hemolysis of RBCs in the samples of MSNs at concentrations, ranging 20-100 μgcm-3.

引用

页码：57 / 62

页数：6

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