Identification of novel regulators associated with early-phase osteoblast differentiation

被引：76

作者：

de Jong, DS

Vaes, BLT

Dechering, KJ

Feijen, A

Hendriks, JMA

Wehrens, R

Mummery, CL

van Zoelen, EJJ

Olijve, W

Steegenga, WT

机构：

[1] Univ Nijmegen, Dept Cell Biol, Fac FNWI, NL-6525 ED Nijmegen, Netherlands

[2] Univ Nijmegen, Dept Appl Biol, NL-6525 ED Nijmegen, Netherlands

[3] NV Organon, Target Discovery Unit, Oss, Netherlands

[4] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

[5] Univ Nijmegen, Dept Analyt Chem, Nijmegen, Netherlands

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 06期

关键词：

microarrays; osteoblast; bone morphogenetic protein 2; differentiation; transcription factors;

D O I：

10.1359/JBMR.040216

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key regulatory components of the BMP-induced osteoblast differentiation cascade remain to be established. Microarray and subsequent expression analyses in mice identified two transcription factors, Hey1 and Tcf7, with in vitro and in vivo expression characteristics very similar to Cbfa1. Transfection studies suggest that Tcf7 modulates BMP2-induced osteoblast differentiation. This study contributes to a better definition of the onset of BMP-induced osteoblast differentiation.

引用

页码：947 / 958

页数：12

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