Linking cerebrovascular defense mechanisms in brain ageing and Alzheimer's disease

被引：38

作者：

Kalaria, Raj N. ^{[1
,2
]}

机构：

[1] Newcastle Gen Hosp, Inst Ageing & Hlth, Wolfson Res Ctr Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[2] Univ Newcastle, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 09期

基金：

英国医学研究理事会;

关键词：

Ageing; Alzheimer's disease; Angiotensin converting enzyme; Cerebral blood flow; Intracellular adhesion molecule; Parieto-temporal lobe; CHOROID-PLEXUS; WHITE-MATTER; BLOOD; BARRIER; VESSELS;

D O I：

10.1016/j.neurobiolaging.2007.10.020

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Apart from the cardiovascular system, several cerebrovascular defense mechanisms inherently function to maintain homeostasis of the neurovascular unit. Prevailing evidence suggests that cerebrovascular functions decline differentially during normal ageing with pronounced effects in Alzheimer's disease (AD). This commentary highlights how vascular regulatory mechanisms may change with age and precede disease to explain the interesting links between changes in the cerebral endothelium, cerebral blood flow (CBF) and functional hyperemia during ageing that are already apparent in AD. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：1512 / 1514

页数：3

共 17 条

[1] Fluctuations of CSF amyloid-β levels -: Implications for a diagnostic and therapeutic biomarker [J].