A CHD1 gene is Z chromosome linked in the chicken Gallus domesticus

被引：87

作者：

Griffiths, R ^{[1
]}

Korn, RM ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT GENET,CAMBRIDGE CB2 1JR,ENGLAND

来源：

GENE | 1997年 / 197卷 / 1-2期

基金：

英国惠康基金;

关键词：

CHD-Z; CHD-W; Z chromosome; avian; sex identification;

D O I：

10.1016/S0378-1119(97)00266-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromo-helicase-DNA binding 1 (CHD1) is a conserved protein with a putative role in chromatin architecture. Single homologues have been found in mouse, Drosophila and yeast. In birds the situation is different as they possess two homologues. One is known to be W-linked, we show the second, closely related gene is linked to the Z sex chromosome. The basic structure of the Z-linked gene is similar to the homologous genes, however, it does possess an additional, internal 88 amino acid hydrophilic domain, rich in glutamic acid and lysine. Studies on pairs of genes sex-linked in mammals suggests rapid divergence of DNA sequence and function. We suggest the DNA sequences of CHD-W and CHD-Z do not follow this pattern. (C) 1997 Elsevier Science B.V.

引用

页码：225 / 229

页数：5

共 10 条

[1] A MAMMALIAN DNA-BINDING PROTEIN THAT CONTAINS A CHROMODOMAIN AND AN SNF2 SWI2-LIKE HELICASE DOMAIN [J].