Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease

被引：73

作者：

Marks, DL ^{[1
]}

Pagano, RE ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0962-8924(02)02399-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocytosis of GSLs, the involvement of sphingolipid-cholesterol interactions in perturbation of endocytic trafficking, and potential roles for rab proteins in regulation of GSL transport in SLSDs.

引用

页码：605 / 613

页数：9

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