Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis

被引：214

作者：

Naeve, GS ^{[1
]}

Ramakrishnan, M ^{[1
]}

Kramer, R ^{[1
]}

Hevroni, D ^{[1
]}

Citri, Y ^{[1
]}

Theill, LE ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT HORMONE RES,IL-76100 REHOVOT,ISRAEL

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 06期

关键词：

D O I：

10.1073/pnas.94.6.2648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression, A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity, This molecule, named neuritin, is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult, Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures, These data implicate neuritin as a downstream effector of activity-induced neurite outgrowth.

引用

页码：2648 / 2653

页数：6

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