An Efficient and Scalable Ritter Reaction for the Synthesis of tert-Butyl Amides

被引：72

作者：

Baum, Jean C. ^{[1
]}

Milne, Jacqueline E. ^{[1
]}

Murry, Jerry A. ^{[1
]}

Thiel, Oliver R. ^{[1
]}

机构：

[1] Amgen Inc, Chem Proc R&D, Thousand Oaks, CA 91320 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 05期

关键词：

NITRILES; ACID;

D O I：

10.1021/jo8024797

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A scalable procedure for the conversion of nitriles to N-tert-butyl amides via the Ritter reaction was optimized employing tert-butyl acetate and acetic acid. The reaction has a broad scope for aromatic, alkyl, and alpha,beta-unsaturated nitriles.

引用

页码：2207 / 2209

页数：3

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