Cell signaling and function organized by PB1 domain interactions

被引：163

作者：

Moscat, Jorge

Diaz-Meco, Maria T.

Albert, Armando

Campuzano, Sonsoles

机构：

[1] Univ Cincinnati, Dept Genome Sci, Genome Res Inst, Cincinnati, OH 45237 USA

[2] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Consejo Super Invest Cient, E-28049 Madrid, Spain

[3] CSIC, Inst Quim Fis Rocasolano, E-28006 Madrid, Spain

来源：

MOLECULAR CELL | 2006年 / 23卷 / 05期

关键词：

D O I：

10.1016/j.molcel.2006.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like P-grasp folds that interact with each other in a front-to-back mode to arrange heterodimers or homo-oligomers. The different PB1 domain adaptors provide specificity for PB1 kinases to ensure the effective transmission of cellular signals. Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions.

引用

页码：631 / 640

页数：10

共 98 条

[1] Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells [J].